The Hematology Department of the Second Hospital of Shandong University is characterized by cellular therapy, such as autologous and allogeneic hematopoietic stem cell transplantation, immunotherapy (i.e., NK cells, CAR-T cells) and mysenchymal stem cells (MSCs), and has unique insights into the treatment of multiple myeloma (MM), hemophagocyic histiocytosis (HLH) and aplastic anemia (AA).
The Hematology Department is a member of MM and Plasma Cell Disease Group of Scientific Committee of Hematological Malignancy of China Anti-Cancer Association and a member of China Alliance for Blood Diseases. It is one of the registered Institutes for Clinical Research on Stem Cells in China, and is an International Cooperation Center for MM Diagnosis and Treatment, and the Shandong-Sweden Cooperative Research Center for Research in Hematological Malignancies.
The Department was identified as the MOH Clinical Pharmacology Base in 2005, granted with rights to award the master's degree in 2002 and the doctoral degree in 2010 by Shandong University respectively, and selected as a postdoctoral workstation in 2012. Biotherapy Institute for Hematological Maligancies of Shandong University was established in 2010.
The Hematology Department consists of the outpatient, the ward, bone marrow transplantation wards, and the GMP laboratory.
Medical Members
The Department now owns 31 medical members, including 14 doctors, 1 doctoral supervisor, 1 chief physicians, and 6 associate chief physicians. The GMP laboratory is staffed by 3 members. All doctors in the Department and technicians from the laboratory have a doctoral or master’s degree.
Clinical Medicine
In addition to clinical work on diagnosis and treatment of various blood diseases, autologous and allogeneic hematopoietic stem cell transplantation and micro-transplantation are also implemented. The Department complies with international standards in the diagnosis and treatment of hematologic tumor (leukemia, lymphoma, myeloma), and standardizes diagnosis and treatment according to the NCCN guidelines and Chinese expert consensus. Furthermore, it has unique advantages and a certain influence in China in the field of diagnosis and treatment of HLH and MM, hematologic tumor immunotherapy and stem cells treatment of blood diseases.
The discipline construction adheres to the patient-centered development concept, and is based on the standardization of disease diagnosis and treatment, combined with advanced technologies and domestic and foreign cooperation in diagnosis and treatment. The discipline is characterized by the diagnosis and treatment of MM, HLH, AA and other diseases as well as cell (immunocyte/stem cells) therapy.
Scientific Research Level, Academic Exchange and Cooperation
The Hematology Department has undertaken nearly 50 research subjects of the state, the province, the ministries and the commissions with total research grant exceeding RMB 3 million Yuan. It has published more than 290 papers on domestic and foreign journals, with more than 90 included by SCI, won 6 national, provincial and ministerial awards for science and technology progress and 3 honorary awards from the state, the province, the ministries and the commissions.
In 2010, led by Prof. Zheng Chengyun, the Director of the Hematology Department, the Biotherapy Institute for Hematological Maligancies of Shandong University was founded; in 2012, the Cell Therapy Department of the Second Hospital of Shandong University was set up. In the same year, the Special Committee of Stem Cells and Regenerative Medical Science of Shandong Society of Biomedical Engineering was found under the leadership of the Department. In 2014, Prof. Zheng Chengyun was appointed as the Director of Shandong University-Karolinska Medical School Stem Cell Research Collaboratory. In the same year, the laboratory was approved as the Key Laboratory of Hematology by the Health Department of Shandong Province. In 2015, the Department cooperated with the Institute of Zoology, Chinese Academy of Sciences to establish the WPOS Special Clinical Research Base of Stem Cells and Regenerative Medicine, Chinese Academy of Sciences. The Second Hospital of Shandong University MM Diagnostic and Treatment International Cooperation Center was established in 2017. In the same year, an application for the establishment of the STEM Cells Clinical Research Institute was filed. One year later, the Shandong Provincial Stem Cells Society, the Special Committee on Technology and Clinical Application of Stem Cells of Shandong Provincial Stem Cells Society, and the Special Committee on Hematopathy of Shandong Society of Geriatrics were set up under its leadership.
In the past twenty years, 5 experts were sent to USA, Sweden and Israel for advanced studies, and academic exchanges for hundreds of person-times were held.
In succession, many experts from USA, Sweden, Germany, France, Portuguesa and other countries were invited for scientific research/clinical academic exchange. Good and close clinical and scientific research cooperative relationship have been built with the National Stem Cells Key Laboratory of Chinese Academy of Science, Sweden Karolinska Institute (Prof. Magnus Nordenskjold, the president of the Election Committee of Karolinska Institute Nobel Prize in Medicine and Physiology; Prof. Jan－Inge Henter, the world renowned HLH expert, the member of the Election Committee of Karolinska Institute Nobel Prize in Medicine and Physiology, and Prof. Magnus Björkholm, a famous lymphoma specialist) as well as the team of Prof. Yi Qing, a specialist in MM experimental immunology with global fame from the USA Cleveland Clinic Cancer Biology Centre and the director of Cleveland Clinic Cancer Biology Department.
Members of the Department have actively attended many global, international and domestic academic conferences, convened and organized many domestic and provincial academic conferences. The Annual Conference of the Special Committee of Stem Cells and Regenerative Medical Science of Shandong Society of Biomedical Engineering has been held once a year since 2012 and invited many international and domestic famous experts of stem cells, fundamentals and clinicians of immunotherapy to the Province for academic exchange.